The Department of Translational Genome Sciences in Translational Biology (Research & Early Development) is responsible for applying human genetic & genomic discoveries to support Biogen’s drug discovery research teams and clinical development programs.
We seek to discover transformative medicines for patients with neurodegenerative disease by leveraging new understanding of human disease biology, genetics, and cutting-edge technologies allowing deeper analysis of pathogenic mechanisms. Pushing back the frontier of neurological disease therapeutics lies at the center of Biogen’s mission.
The RNA Biology and Functional Genomics group, within Translational Genome Sciences, is seeking a highly skilled and motivated scientist to join a dynamic team dedicated to understanding the molecular basis of and developing novel therapeutics for neurological disorders.
The candidate will work independently and with other experimentalists, computational biologists, and statistical geneticists to further our understanding of how genetic variation and RNA metabolism impact disease and to define novel therapeutic hypotheses. This is primarily a laboratory based position for a scientist with strong molecular and cellular biology skills and deep understanding of RNA biology to study the effects of genetic variants on the transcriptome and proteome. The key elements for success are deep technical expertise, a passion for doing science, and ability to communicate effectively with molecular and computational scientists.
Partner with leaders in Translational Biology, Disease-Area Research, Biomarkers, and Clinical Development to identify key questions and priorities that functional genomics experiments can impact;
Design and execute functional genomics experiments to support Biogen’s drug discovery efforts in neurology and rare genetic disease;
Deliver experimental results to project teams that help define therapeutic hypothesis and/or targeting strategy; and
Identify opportunities for external collaborations that supplement internal resources and ensure RNA biology and functional genomics research is at the cutting edge.
Proven expertise in molecular and cellular biology techniques, including CRISPR/Cas9 engineering, mammalian cell culture, and modern cloning techniques;
Deep knowledge of post-transcriptional regulation of RNAs, including its processing, localization, and degradation; • Demonstrated ability to work independently by designing, executing, and troubleshooting experiments;
Advanced experience with RNA assays and genomic/transcriptomic approaches to solve biological problems;
Strong collaboration, organizational, and communication skills and an ability to work well in a team setting; and
Sharp ability to learn and adapt to work on new tasks and projects that he/she may not have worked on previously.
Expertise in ncRNA and/or miRNA regulation;
Expertise in iPSC culture and differentiation; and
Proficiency in computational approaches to data analysis
Ph.D. in Molecular and Cellular Biology, Genetics, or Genomics
Internal Number: 34936BR
About Biogen, Inc.
Biogen seeks to discover transformative medicines for patients with Multiple Sclerosis (MS) by leveraging new understanding of human disease biology, genetics, and cutting-edge technologies allowing deeper analysis of pathogenic mechanisms. Pushing back the frontier of neurological disease therapeutics lies at the center of Biogen’s mission.